Renal function following long-term weight loss in individuals with abdominal obesity on a very-low-carbohydrate diet vs high-carbohydrate diet.
"Renal function following long-term weight loss in individuals with abdominal obesity on a very-low-carbohydrate diet vs high-carbohydrate diet. Brinkworth GD, Buckley JD, Noakes M et al. Journal of the American Dietetic Association. 2010 Apr;110(4):633-8. "
"A frequently cited concern of very-low-carbohydrate (VLCHF) diets is the potential for increased risk of renal disease associated with a higher protein intake. However, to date, no well-controlled randomized studies have evaluated the long-term effects of very-low-carbohydrate diets on renal function. Aim: to access the effects on renal function of a long-term VLCHF diet."
"Primary: markers of renal function (serum creatinine, estimated glomerular ﬁltration rate [eGFR] and urinary albumin excretion) Secondary: weight, BMI"
"Weight loss was SS WG for both diets; BG differences NSS. No SS change in either diet for creatinine or eGFR."
relatively high dropout rate (42%) but compliance to diet protocols appeared to be good in those who completed the stuy
"Kidney function: eGFR, creatinine WG: N BG: N No SS change in either diet group one test for eGFR showed decrease in both diet groups; decrease was related to reduced body surface area and weight, not diet."
"This study provides preliminary evidence that long-term weight loss with a VLC diet does not adversely affect renal function compared with a HC diet in obese individuals with normal renal function."
AHA - American Heart Association;
ALT - alanine aminotransferase;
AMDR - acceptable macronutrient distribution range;
AST - aspartate aminotransferase;
BG - between study groups;
BHOB - beta-hydroxybutyrate;
DBP - diastolic blood pressure;
E- energy, caloric intake;
eGFR - estimated glomerular filtration rate;
FBG - fasting blood glucose;
GGT - gamma-glutamyl transferase;
HDL-C - high-density lipoprotein cholesterol;
iGFR - isotope glomerurar filtration rate;
LDL-C - low-density lipoprotein cholesterol;
NAFLD - non-alcoholic fatty liver disease;
NR - not reported (or data needed for calculation not available);
N - no;
NA - not applicable;
NS - not specified;
NSS - not statistically significant;
SBP - systolic blood pressure;
SS - statistically significant;
TG - triglyceride;
total C - total cholesterol;
V - varied, mixed;
WG - within a study group;
WMD - weighted mean difference;
Y - yes
Number of People in Studies:
3,296 Enrolled in randomized controlled trials on 25% or less carbohydrates
2,626 Completed randomized controlled trials on 25% or less carbohydrates
79.67% 82% completion of studies
Duration of Trial
1 -2 years
# of Trials
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