Randomized clinical trial of standard dietary treatment versus a low-carbohydrate/ high-protein diet or the LighterLife Programme in the management of obesity.
"Randomized clinical trial of standard dietary treatment versus a low-carbohydrate/ high-protein diet or the LighterLife Programme in the management of obesity. C Rolland, M Hession, S Murray et al. Journal of Diabetes. 2009 Sep;1(3):207-17. Epub 2009 Jun 26. "
"To assess changes in weight, body composition and CVD risk in response to a very low-carbohydrate, high- protein diet (VLC+HP) or a moderately low-carb, E-restricted (Mod Carb) diet with commercial foods provided. "
Primary: weight, body composition, CVD risk factors
"Some WG levels NR. For reporting here, the VLC+HP diet is regarded as the low-carb diet, although both tests were within range by definition of low/moderate carb intake. Greater WG (and some SS BG) improvement was seen with the Moderate Carb diet, which offered significantly greater behavioral support to subjects."
"Renal and hepatic markers Neither diet group had adverse levels, but some WG and BG outcomes were SS: Urea - LC+HP diet: WG SS increase - Mod Carb diet: WG SS decrease BG SS p=0.03 Creatinine - LC+HP diet: WG NSS - Mod Carb diet: WG SS decrease BG NSS eGFR - LC+HP protein diet: WG NSS - Mod Carb diet: WG SS increase BG SS p=0.035 Alanine aminotransferase c-Glutamyl transferase - LC+HP diet: WG NSS - Mod Carb diet: Both WG SS decreases BG SS p=0.016, 0.008 "
"Greater weight loss and improved CV risk were achieved with the LL [Moderate Carb diet], which mostly reﬂects the patient support provided for each dietary treatment."
AHA - American Heart Association;
ALT - alanine aminotransferase;
AMDR - acceptable macronutrient distribution range;
AST - aspartate aminotransferase;
BG - between study groups;
BHOB - beta-hydroxybutyrate;
DBP - diastolic blood pressure;
E- energy, caloric intake;
eGFR - estimated glomerular filtration rate;
FBG - fasting blood glucose;
GGT - gamma-glutamyl transferase;
HDL-C - high-density lipoprotein cholesterol;
iGFR - isotope glomerurar filtration rate;
LDL-C - low-density lipoprotein cholesterol;
NAFLD - non-alcoholic fatty liver disease;
NR - not reported (or data needed for calculation not available);
N - no;
NA - not applicable;
NS - not specified;
NSS - not statistically significant;
SBP - systolic blood pressure;
SS - statistically significant;
TG - triglyceride;
total C - total cholesterol;
V - varied, mixed;
WG - within a study group;
WMD - weighted mean difference;
Y - yes
Number of People in Studies:
3,296 Enrolled in randomized controlled trials on 25% or less carbohydrates
2,626 Completed randomized controlled trials on 25% or less carbohydrates
79.67% 82% completion of studies
Duration of Trial
1 -2 years
# of Trials
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